January 02, 2013 - THAILAND - Clipboard in hand, Dr Francois Nosten worked his way down a ward of malaria patients. He stopped in front of five-year-old Ayemyint Than, who sat to attention and smiled. The smile told Nosten as much as his lines of graphs and figures.
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Staff examine a baby who has been brought to the clinic with a fever, suspected to be malaria.
Ian Williams / NBC News. |
"She's doing well," he said, moving to an older man, whose pale face and dull sunken eyes told a very different story. "Day five, and he's still positive?" he asked another of the doctors. "That's not very good. It means he was very slow to clear the parasite, no?" To Nosten, it was further evidence of an alarming rise in resistance to artemisinin, currently the front-line drug in the treatment of malaria. He fears it could be the start of a global "nightmare" in which millions of people could lose their lives. "We have to beat this resistance, win this race and eliminate the parasite before it’s too late. That's our challenge now," he said. He said that artemisinin should take about 24 hours to deal with the parasite, but it was now taking three or four days in some cases. "We are going to see patients that don't respond to the treatment anymore,” he warned. Nosten runs the Shoklo Malaria Research Unit, which is part of the Faculty of Tropical Medicine at Thailand's Mahidol University. The unit has a string of clinics on both sides of the Moi River, which marks the porous border between Thailand and Myanmar.
Nosten set up the first one in 1986, since when there has been a steady fall in the total number of cases of malaria, but most recently a worrying emergence of drug resistance. He first sounded the alarm in research published earlier this year, following the emergence of similar drug resistance along the Thai-Cambodia border. Nosten’s not sure whether the resistance he's found has spread from the Cambodia border or is home-grown. Either way, he's worried. "It means that all the progress of the last 10 to 15 years will be lost," he warned. "Now the resistance is here, we worry that we are running out of time." The malaria parasite -- carried by infected mosquitoes from person to person -- still kills an estimated 655,000 people a year. That's almost 2,000 a day, mostly in Africa, with children being most at risk. If the world loses its front-line drug, the impact could be devastating. "The nightmare scenario is that the resistance will travel," Nosten said. "We know what will happen in Africa when resistance is bad because we've been there before in the 1990s with chloroquine (another anti-malarial drug) … millions of deaths," he warned. "We must prevent artemisinin resistance reaching Africa, but we also need to control it for the people in Asia - for their future." -
MSNBC.
WATCH: Scientists are battling to stop a drug-resistant malaria that could threaten the lives of millions. "We worry that we are running out of time," one scientist says. NBC News' Ian Williams reports from northwestern Thailand.